What’s in the draft genome sequence?
Features found in DNA & their structure
- Genes (coding regions & their control regions)
- Junk DNA (simple repeats, “dead” viruses, pseudo-genes)
How to hunt for genes
- Homology methods - compare DNA sequence to database of known genes (high accuracy)
- Ab initio prediction (low accuracy)
- Experimental methods (high accuracy)
Bioinformatics - putting it all together
- Annotation - combining expert knowledge & algorithms
- Visualization - picture paints 1000 words
- interconnecting databases