Multiple levels of regulation
mevalonate
1.1.1.34
2 NADP+; HSCoA
2 NADPH; 2H+
catalyzes
inhibits
inhibits
ER membrane
acetoactetyl-CoA
2.3.1.9
beta-ketothiolyase
catalyzes
HSCoA
HMG-CoA
4.1.3.5
HMG-CoA synthase
HSCoA
acetyl-CoA; H2O
catalyzes
2
inhibits
inhibits
cytosol
acetyl-CoA
acetyl-CoA
acetoactetyl-CoA
2.3.1.9
beta-ketothiolyase
catalyzes
HSCoA
HMG-CoA
4.1.3.5
HMG-CoA synthase
HSCoA
acetyl-CoA; H2O
catalyzes
mevalonate
1.1.1.34
HMG-CoA reductase
HMG-CoA reductase
2 NADP+; HSCoA
2 NADPH; 2H+
catalyzes
HMGCR
HMGCR
inhibits
inhibits
inhibits
non sterol metabolites
non sterol metabolites
HMGCR mRNA
HMGCR mRNA
is transcribed
is transcribed
is translated
inhibits
inhibits
sterol biosynthesis
sterol biosynthesis
degrades
degrades
protein kinase
protein kinase
inhibits
beta oxidation of fatty acids
beta oxidation of fatty acids
glycolysis
cytosol
ER membrane
2
LDL
LDL
inhibits
inhibits
ACAT1
ACAT1
codes for
codes for
HMGCS1
HMGCS1
codes for
codes for
SREPB
SREPB
SREBP pathway
SREBP pathway
up-regulates
up-regulates
up-regulates
up-regulates
is translated
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