Methionine Biosynthesis in S.cerevisiae

MET31

MET32

MET28

MET4

CBF1

Cbf1p/Met4p/Met28p

complex

Met31pmet32p

Met30p

MET30

GCN4

Gcn4p

HOM6

MET2

MET17

HOM3

MET6

SAM1

SAM2

HOM2

Homoserine deshydrogenase

Homoserine O-acetyltransferase

O-acetylhomoserine (thiol)-lyase

Aspartate kinase

Methionine synthase (vit B12-independent)

S-adenosyl-methionine synthetase I

S-adenosyl-methionine synthetase II

Aspartate semialdehyde deshydrogenase

O-acetyl-homoserine

L-aspartyl-4-P

L-Aspartate

L-Homoserine

Homocysteine

L-Methionine

S-Adenosyl-L-Methionine

L-aspartic semialdehyde

1.1.1.3

2.3.1.31

4.2.99.10

2.7.2.4

2.1.1.14

2.5.1.6

1.2.1.11

NADP+

NADPH

CoA

AcetlyCoA

Sulfide

ADP

ATP

5-tetrahydropteroyltri-L-glutamate

5-methyltetrahydropteroyltri-L-glutamate

Pi, PPi

H20; ATP

NADP+; Pi

NADPH

Sulfur assimilation

Cysteine biosynthesis

Threonine biosynthesis

Aspartate biosynthesis

Figure *

exp

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