Current TOPS project, joint with Leeds (Biochem)
“Patterns, functions and structures on a protein topology database” (UK Government funded)
Addition of SSE spatial neighbour information, helix packing classes & chirality relationships
Addition of sequence, ligand binding information and EC number
TOPS visualization methods
Improvement of current search, machine learning and structure comparison algorithms & adaptation to new structural data
Development of relational database
Learning algorithms to relate topology to sequence and to function