Case study GHKL an emergent ATPase/kinase superfamily
Dutta R, Inouye M, Trends Biochem Sci 2000 Jan;25(1):24-8
Novel ATP-binding superfamily, includes
- DNA topoisomerase II
- molecular chaperones Hsp90
- DNA-mismatch-repair enzymes MutL
- histidine kinases.
The most singular unifying feature - unconventional Bergerat ATP-binding fold.
The far-reaching significance of this commonality is still in the process of being explored.