History
TOPS diagrams (“cartoons”) - optimal projection of protein 3-dimensional structures in 2 dimensions.
Used for understanding & manual comparison of protein folds.
Originally drawn manually [Sternberg+77]
Now produced automatically from Brookhaven Protein Data Bank (PDB) [Flores+94, Westhead+98] (via dssp program)
On-line atlas at EBI, search by protein domain name.
Computation using TOPS descriptions