cpn  [levchenko]
{
constants:
  valuesets[Main:V_Set_1:V_Set_2:V_Set_3]
marking:
  double n_M_Raf = [4:8:40:400];
  double n_M_RasGTP = [1:2:10:100];
  double n_M_ERK = [3:6:30:300];
  double n_M_Phase2 = [2:4:20:200];
  double n_M_Phase3 = [3:6:30:300];
  double n_M_MEK = [2:4:20:200];
  double n_M_Phase1 = [3:6:30:300];
parameter:
  double k1 = [1.0:::];
  double k10 = [3.3:::];
  double k4 = [0.5:::];
  double k3 = [0.1:::];
  double k6 = [0.1:::];
  double k7 = [3.3:::];
  double k8 = [0.42:::];
  double k9 = [0.1:::];
  double k2 = [0.4:::];
  double k21 = [0.1:::];
  double k22 = [20.0:::];
  double k23 = [0.6:::];
  double k24 = [0.1:::];
  double k25 = [5.0:::];
  double k26 = [0.4:::];
  double k27 = [0.1:::];
  double k28 = [5.0:::];
  double k29 = [0.4:::];
  double k30 = [0.1:::];
  double k11 = [0.4:::];
  double k12 = [0.1:::];
  double k13 = [10.0:::];
  double k14 = [0.8:::];
  double k15 = [0.1:::];
  double k16 = [10.0:::];
  double k17 = [0.8:::];
  double k18 = [0.1:::];
  double k19 = [20.0:::];
  double k20 = [0.6:::];
  double sf = [0.1:0.05:0.01:0.001];
  double k5 = [0.5:::];

places:
   M_Raf = n_M_Raf;
   M_RasGTP = n_M_RasGTP;
   M_Raf_M_RasGTP = 0;
   M_RafP = 0;
   M_RafP_M_Phase1 = 0;
   M_MEK_M_RafP = 0;
   M_MEKP_M_RafP = 0;
   M_MEKP_M_Phase2 = 0;
   M_MEKPP_M_Phase2 = 0;
   M_ERK = n_M_ERK;
   M_ERK_M_MEKPP = 0;
   M_ERKP_M_MEKPP = 0;
   M_ERKP = 0;
   M_MEKPP = 0;
   M_ERKPP_M_Phase3 = 0;
   M_ERKP_M_Phase3 = 0;
   M_MEKP = 0;
   M_ERKPP = 0;
   M_Phase2 = n_M_Phase2;
   M_Phase3 = n_M_Phase3;
   M_MEK = n_M_MEK;
   M_Phase1 = n_M_Phase1;

transitions:
  R_TC_0_k3
    : 
    : [M_RafP + 1] & [M_RasGTP + 1] & [M_Raf_M_RasGTP - 1]
    : k3 * M_Raf_M_RasGTP
    ;
  R_TC_1_k6
    : 
    : [M_Raf + 1] & [M_Phase1 + 1] & [M_RafP_M_Phase1 - 1]
    : k6 *M_RafP_M_Phase1
    ;
  R_TC_2_k21
    : 
    : [M_ERKP + 1] & [M_MEKPP + 1] & [M_ERK_M_MEKPP - 1]
    : k21 *M_ERK_M_MEKPP
    ;
  R_TC_3_k18
    : 
    : [M_MEK + 1] & [M_Phase2 + 1] & [M_MEKP_M_Phase2 - 1]
    : k18 * M_MEKP_M_Phase2
    ;
  R_TC_4_k9
    : 
    : [M_MEKP + 1] & [M_RafP + 1] & [M_MEK_M_RafP - 1]
    : k9 * M_MEK_M_RafP
    ;
  R_TC_5_k12
    : 
    : [M_MEKPP + 1] & [M_RafP + 1] & [M_MEKP_M_RafP - 1]
    : k12 * M_MEKP_M_RafP
    ;
  R_TC_6_k15
    : 
    : [M_Phase2 + 1] & [M_MEKP + 1] & [M_MEKPP_M_Phase2 - 1]
    : k15 * M_MEKPP_M_Phase2
    ;
  R_TC_7_k24
    : 
    : [M_ERKPP + 1] & [M_MEKPP + 1] & [M_ERKP_M_MEKPP - 1]
    : k24 * M_ERKP_M_MEKPP
    ;
  R_TC_8_k1
    : 
    : [M_Raf_M_RasGTP + 1] & [M_Raf - 1] & [M_RasGTP - 1]
    : k1 * M_Raf* M_RasGTP* sf
    ;
  R_TC_9_k2
    : 
    : [M_RasGTP + 1] & [M_Raf + 1] & [M_Raf_M_RasGTP - 1]
    : k2 * M_Raf_M_RasGTP
    ;
  R_TC_10_k27
    : 
    : [M_Phase3 + 1] & [M_ERKP + 1] & [M_ERKPP_M_Phase3 - 1]
    : k27 * M_ERKPP_M_Phase3
    ;
  R_TC_11_k30
    : 
    : [M_ERK + 1] & [M_Phase3 + 1] & [M_ERKP_M_Phase3 - 1]
    : k30 * M_ERKP_M_Phase3
    ;
  R_TC_12_k16
    : 
    : [M_MEKP_M_Phase2 + 1] & [M_Phase2 - 1] & [M_MEKP - 1]
    : k16 * M_Phase2 * M_MEKP *sf
    ;
  R_TC_13_k17
    : 
    : [M_Phase2 + 1] & [M_MEKP + 1] & [M_MEKP_M_Phase2 - 1]
    : k17 * M_MEKP_M_Phase2
    ;
  R_TC_14_k29
    : 
    : [M_Phase3 + 1] & [M_ERKP + 1] & [M_ERKP_M_Phase3 - 1]
    : k29 * M_ERKP_M_Phase3
    ;
  R_TC_15_k28
    : 
    : [M_ERKP_M_Phase3 + 1] & [M_Phase3 - 1] & [M_ERKP - 1]
    : k28 * M_Phase3 * M_ERKP * sf
    ;
  R_TC_16_k14
    : 
    : [M_Phase2 + 1] & [M_MEKPP + 1] & [M_MEKPP_M_Phase2 - 1]
    : k14 * M_MEKPP_M_Phase2
    ;
  R_TC_17_k13
    : 
    : [M_MEKPP_M_Phase2 + 1] & [M_Phase2 - 1] & [M_MEKPP - 1]
    : k13 * M_Phase2 * M_MEKPP * sf
    ;
  R_TC_18_k5
    : 
    : [M_Phase1 + 1] & [M_RafP + 1] & [M_RafP_M_Phase1 - 1]
    : k5 * M_RafP_M_Phase1
    ;
  R_TC_19_k4
    : 
    : [M_RafP_M_Phase1 + 1] & [M_Phase1 - 1] & [M_RafP - 1]
    : k4 * M_Phase1 * M_RafP * sf
    ;
  R_TC_20_k26
    : 
    : [M_Phase3 + 1] & [M_ERKPP + 1] & [M_ERKPP_M_Phase3 - 1]
    : k26 * M_ERKPP_M_Phase3
    ;
  R_TC_21_k25
    : 
    : [M_ERKPP_M_Phase3 + 1] & [M_Phase3 - 1] & [M_ERKPP - 1]
    : k25 * M_Phase3 * M_ERKPP * sf
    ;
  R_TC_22_k11
    : 
    : [M_RafP + 1] & [M_MEKP + 1] & [M_MEKP_M_RafP - 1]
    : k11 * M_MEKP_M_RafP
    ;
  R_TC_23_k8
    : 
    : [M_RafP + 1] & [M_MEK + 1] & [M_MEK_M_RafP - 1]
    : k8 * M_MEK_M_RafP
    ;
  R_TC_24_k23
    : 
    : [M_MEKPP + 1] & [M_ERKP + 1] & [M_ERKP_M_MEKPP - 1]
    : k23 * M_ERKP_M_MEKPP
    ;
  R_TC_25_k20
    : 
    : [M_MEKPP + 1] & [M_ERK + 1] & [M_ERK_M_MEKPP - 1]
    : k20 * M_ERK_M_MEKPP
    ;
  R_TC_26_k7
    : 
    : [M_MEK_M_RafP + 1] & [M_RafP - 1] & [M_MEK - 1]
    : k7 * M_RafP * M_MEK * sf
    ;
  R_TC_27_k10
    : 
    : [M_MEKP_M_RafP + 1] & [M_RafP - 1] & [M_MEKP - 1]
    : k10 * M_RafP*M_MEKP*sf
    ;
  R_TC_28_k19
    : 
    : [M_ERK_M_MEKPP + 1] & [M_MEKPP - 1] & [M_ERK - 1]
    : k19 * M_MEKPP*M_ERK * sf
    ;
  R_TC_29_k22
    : 
    : [M_ERKP_M_MEKPP + 1] & [M_MEKPP - 1] & [M_ERKP - 1]
    : k22 * M_MEKPP * M_ERKP * sf
    ;

}